One-Pot Synthesis of Chiral Tetracyclic Dibenzo[ b, f][1,4]oxazepine-Fused 1,2-Dihydropyridines (DHPs) under Metal-Free Conditions
| dc.contributor.author | Kumar, Indresh | |
| dc.date.accessioned | 2021-10-27T04:27:24Z | |
| dc.date.available | 2021-10-27T04:27:24Z | |
| dc.date.issued | 2018-06 | |
| dc.description.abstract | An efficient protocol for the catalytic asymmetric synthesis of new dibenzo[b,f][1,4]-oxazepine-fused 1,2-dihydropyridines (DHPs) has been described under metal-free conditions. This reaction proceeds through proline-catalyzed direct Mannich/cyclization between seven-membered dibenzo[b,f][1,4]-oxazepine-imines and aqueous glutaraldehyde, followed by IBX-mediated site-selective dehydrogenative oxidation in one-pot operation with high yields (up to 92%) and excellent enantioselectivity (up to >99:1 er). | en_US |
| dc.identifier.uri | https://pubs.acs.org/doi/10.1021/acs.joc.8b01232 | |
| dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3163 | |
| dc.language.iso | en | en_US |
| dc.publisher | ACS | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Catalysts | en_US |
| dc.subject | Oxidation | en_US |
| dc.subject | Reaction products | en_US |
| dc.title | One-Pot Synthesis of Chiral Tetracyclic Dibenzo[ b, f][1,4]oxazepine-Fused 1,2-Dihydropyridines (DHPs) under Metal-Free Conditions | en_US |
| dc.type | Article | en_US |
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