Synthesis and Biological Evaluation of 2-Arylamino-5- (3′-Indolyl)-1,3,4-Oxadiazoles as Potent Cytotoxic Agents

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dc.contributor.authorKumar, Anil
dc.contributor.authorKumar, Dalip
dc.date.accessioned2021-10-17T13:59:06Z
dc.date.available2021-10-17T13:59:06Z
dc.date.issued2013
dc.description.abstractCoupling of two key scaffolds in medicinal chemistry, the indole and 1,3,4-oxadiazole ring systems, gave rise to 2-arylamino-5-(3′-indolyl)-1,3,4-oxadiazoles with IC50 values in the nanomolar range against a panel of tumor cell lines. Preliminary structure–activity relationship studies indicate potential for improved selectivity through further manipulation of the oxadiazole C-2 and C-5 positions.en_US
dc.identifier.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201300221
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2895
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectChemistryen_US
dc.subjectSynthesisen_US
dc.subjectBiological Evaluationen_US
dc.subjectPotent Cytotoxic Agentsen_US
dc.titleSynthesis and Biological Evaluation of 2-Arylamino-5- (3′-Indolyl)-1,3,4-Oxadiazoles as Potent Cytotoxic Agentsen_US
dc.typeArticleen_US

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