Effect of pioglitazone on the abrogated cardioprotective effect of ischemic preconditioning in hyperlipidemic rat heart
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Date
2016
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Medknow
Abstract
The signaling pathways upstream of glycogen synthase kinase-3β (GSK-3β) get reduced during ischemic preconditioning (IPC) in hyperlipidemic rat heart. Pioglitazone, an insulin sensitizer, exerts cardioprotection through GSK-3β. The objective of the study is to investigate the role of pioglitazone on the attenuated cardioprotective effect of IPC in hyperlipidemic rat heart.
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Keywords
Pharmacy, Creatinine kinase, Glycogen synthase kinase-3β, Ischemia-reperfusion, Lactate dehydrogenase, Myocardial injury, Pioglitazone, Rapamycin, Wortmannin