Syntheses of Chiral N-(Protected) Tri- and Tetrapeptide Conjugates

Abstract

Cbz-(protected)-tri- and tetrapeptide conjugates with steroids, sugars, terpenes, and heterocycles were prepared using Cbz-(protected)-tri- and tetrapeptidoylbenzotriazoles as active intermediates.Peptides and their derivatives such as hormones, neurotransmitters, and neuromodulators act as signal molecules in diverse biological and medicinal applications and thus have attracted considerable synthetic attention (1, 2). Esterifications of amino acids and peptides for the protection of carboxylic acid functionality and for their activation to make peptide conjugates are well known (3-5).