An organocatalytic direct Mannich–cyclization cascade as [3+2] annulation: asymmetric synthesis of 2,3-substituted pyrrolidines

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dc.contributor.authorKumar, Indresh
dc.date.accessioned2021-10-27T04:28:07Z
dc.date.available2021-10-27T04:28:07Z
dc.date.issued2012
dc.description.abstractA new method for asymmetric synthesis of 2,3-substituted pyrrolidines from N-PMP aldimines and succinaldehyde via formal [3+2] cycloaddition is reported. This reaction involves proline catalyzed direct Mannich reaction and acid catalyzed reductive cyclization with high yields (up to 78%) and excellent enantioselectivities (up to >99%).en_US
dc.identifier.urihttps://pubs.rsc.org/en/content/articlelanding/2012/cc/c2cc33103a
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3178
dc.language.isoenen_US
dc.publisherRSCen_US
dc.subjectChemistryen_US
dc.subjectOrganocatalyticen_US
dc.subjectMannich–cyclizationen_US
dc.subjectPyrrolidinesen_US
dc.titleAn organocatalytic direct Mannich–cyclization cascade as [3+2] annulation: asymmetric synthesis of 2,3-substituted pyrrolidinesen_US
dc.typeArticleen_US

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