Synthesis of modified bile acids via palladium-catalyzed C(sp3)–H (hetero)arylation
| dc.contributor.author | Chitkara, Deepak | |
| dc.contributor.author | Sakhuja, Rajeev | |
| dc.date.accessioned | 2024-01-06T06:45:10Z | |
| dc.date.available | 2024-01-06T06:45:10Z | |
| dc.date.issued | 2023-07 | |
| dc.description.abstract | A Pd(II)-catalyzed strategy for the diastereo- and regioselective (hetero)arylation of unactivated C(sp3)–H bonds in bile acids is accomplished with aryl and heteroaryl iodides under solvent-free conditions using the 8-aminoquinoline auxiliary as a directing group. This methodology demonstrated excellent functional group tolerance with respect to aryl/heteroaryl iodides on O-protected N-(quinolin-8-yl)cholyl/deoxycholyl amides to afford β-C(sp3)–H (hetero)arylated products in good-to-excellent yields. Moreover, the 8-aminoquinoline (AQ) auxiliary can easily be removed to obtain modified bile acids. | en_US |
| dc.identifier.uri | https://pubs.rsc.org/en/content/articlehtml/2023/ob/d3ob00916e | |
| dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13714 | |
| dc.language.iso | en | en_US |
| dc.publisher | RSC | en_US |
| dc.subject | Pharmacy | en_US |
| dc.subject | Synthesis | en_US |
| dc.subject | Bile acids | en_US |
| dc.title | Synthesis of modified bile acids via palladium-catalyzed C(sp3)–H (hetero)arylation | en_US |
| dc.type | Article | en_US |
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