Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy
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Date
2019-03
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Publisher
Elsevier
Abstract
Renin-angiotensin system (RAS) and natriuretic peptides system (NPS) perturbations govern the development of diabetic nephropathy (DN). Hence, in search of a novel therapy against DN, present study targeted both, NPS and RAS simultaneously using a neprilysin inhibitor (NEPi) in combination with either angiotensin receptor blocker (ARB) or angiotensin-converting enzyme 2 (ACE2) activator.
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Keywords
Pharmacy, Diabetic nephropathy, Renin-angiotensin system (RAS), Diabetic nephropathy (DN)