Substrate or Solvent-Controlled PdII-Catalyzed Regioselective Arylation of Quinolin-4(1H)-ones Using Diaryliodonium Salts: Facile Access to Benzoxocine and Aaptamine Analogues

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2020-03-11

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Wiley

Abstract

Substrate or solvent controlled regioselective C3, C5, and C8 arylation of quinolin-4(1H)-ones with diaryliodonium salts have been successfully achieved in high yields (up to 96 %). These protocols are applicable to a wide range of quinolone related heterocycles and provide potential access to naturally occurring benzoxocine and aaptamine analogues

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Chemistry, Diaryliodonium Salts, Benzoxocine, Aaptamine Analogues

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