Rhodium-Catalyzed Annulation of Vinylated Tyrosines with Internal Alkynes to Access Oxepine-Mounted Unnatural Tyrosines and Its Peptide Late Stage Functionalization

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dc.contributor.authorSakhuja, Rajeev
dc.date.accessioned2024-09-13T08:54:22Z
dc.date.available2024-09-13T08:54:22Z
dc.date.issued2022-09
dc.description.abstractA Rh(III)-catalyzed [5+2] annulation of vinyl tyrosines with symmetrical and unsymmetrical internal alkynes was achieved, furnishing a series of oxepine-mounted tyrosine-based unnatural amino acids. In addition, the chemical applicability of the developed strategy was exemplified by stapling amino acid/peptide-appended alkynes with vinyl tyrosines and late stage functionalization of tyrosine-containing dipeptides and tripeptide with internal alkynes.en_US
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acs.orglett.2c02820
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15568
dc.language.isoenen_US
dc.publisherACSen_US
dc.subjectChemistryen_US
dc.subjectAnnulationsen_US
dc.subjectAromatic compoundsen_US
dc.subjectHydrocarbonsen_US
dc.subjectPeptides and proteinsen_US
dc.titleRhodium-Catalyzed Annulation of Vinylated Tyrosines with Internal Alkynes to Access Oxepine-Mounted Unnatural Tyrosines and Its Peptide Late Stage Functionalizationen_US
dc.typeArticleen_US

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