Deciphering the role of IspD (2‑C‑methyl‑D‑erythritol 4‑phosphate cytidyltransferase) enzyme as a potential therapeutic drug target against Plasmodium vivax

Abstract

IspD(2‑C‑methyl‑d-erythritol 4-phosphate cytidyltransferase) PvIspDPlasmodium vivax IspD PfIspDPlasmodium falciparum IspD AtIspDArabidopsis thaliana IspD MEPMethyl erythritol phosphate (Non-mevalonate) HTSHigh Throughput Screening NEATnuclear encoded apicoplast targeted CTPcytidine 5′-triphosphate CDP-ME4-diphosphocytidyl-2C-methyl‑D-erythritol ACDacid citrate dextrose IHECInstitute Human Ethics Committee PCRPolymerase chain reaction MBPMaltose binding protein RIG plasmidPlasmid with arginine (R), Isoleucine (I) and Glycine (G) tRNA genes DOPEDiscrete Optimized Protein Energy pMALMaltose FITCFluorescein isothiocyanate DAPI4′,6-diamidino-2-phenylindole Qdotquantum dot RMSDroot-mean-square deviation