Department of Chemistry

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    A Facile Synthesis and Cytotoxicity of a Novel Porphyrin-Cryptolepine Conjugate
    (CBI, 2012) Kumar, Anil; Kumar, Dalip
    A novel porphyrin–cryptolepine conjugate 7 with a 1,2,3-triazole linker was synthesized by the cycloaddition reaction of propargyl porphyrin 2 and azido cryptolepine 6 under click conditions. The conjugate 7 exhibited enhanced photocytotoxicity against A549 cells with IC50 values of 2.5 μM and 7.9 μM in the visible and UV light, respectively.
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    Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities
    (Elsiever, 2011-03) Kumar, Anil
    A series of two classes of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates were synthesized using click chemistry approach. All compounds were evaluated for inhibition of Src kinase and human ovarian adenocarcinoma (SK-Ov-3), breast carcinoma (MDA-MB-361), and colon adenocarcinoma (HT-29). Hexyl triazolyl-substituted 3-phenylpyrazolopyrimidine exhibited inhibition of Src kinase with an IC50 value of 5.6 μM. 4-Methoxyphenyl triazolyl-substituted 3-phenylpyrazolopyrimidine inhibited the cell proliferation of HT-29 and SK-Ov-3 by 73% and 58%, respectively, at a concentration of 50 μM.