A Facile Synthesis and Cytotoxicity of a Novel Porphyrin-Cryptolepine Conjugate
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Date
2012
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Journal ISSN
Volume Title
Publisher
CBI
Abstract
A novel porphyrin–cryptolepine conjugate 7 with a 1,2,3-triazole linker was synthesized by
the cycloaddition reaction of propargyl porphyrin 2 and azido cryptolepine 6 under click conditions.
The conjugate 7 exhibited enhanced photocytotoxicity against A549 cells with IC50 values of 2.5 μM
and 7.9 μM in the visible and UV light, respectively.
Description
Keywords
Chemistry, Porphyrin, Cryptolepine, 1,2,3-Triazole