Department of Management

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Start date: 2000End date: 2009

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Now showing 1 - 10 of 15
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    Microwave-assisted solvent-free synthesis of 3-[(4-substituted piperazin-1-yl)alkyl] imidazo[2,1-b][1,3]benzothiazol-2(3H)-ones as serotonin3 (5-HT3) receptor antagonists
    (Avoxa, 2005-06) Mahesh, R.
    A series of novel 3-[(4-substituted piperazin-1-yl)alkyl]imidazo[2,1-b][1,3]benzothiazol-2(3H)-ones were prepared by microwave irradiation using alumina as solid support and also by a conventional method. The compounds were characterized by spectral data and the purity was ascertained by microanalysis. The synthesized compounds were evaluated for 5-hydroxytryptamine3 antagonisms in a longitudinal muscle-myenteric plexus preparation from guinea pig ileum against the 5-hydroxytryptamine3 agonist, 2-methyl-5-hydroxytryptamine. Among the test compounds, 3-[2-(4-methylpiperazin-1-yl)ethyl]imidazo[2,1-b][1,3]benzothiazol-2(3H)-one (3b) showed most favorable 5-hydroxytryptamine3 antagonism (pA2 6.7) in the isolated guinea pig ileum.
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    Assessing the Neuronal Serotonergic Target-based Antidepressant Stratagem: Impact of In Vivo Interaction Studies and Knockout Models
    (Bentham Science, 2008) Mahesh, R.
    Depression remains a challenge in the field of affective neuroscience, despite a steady research progress. Six out of nine basic antidepressant mechanisms rely on serotonin neurotransmitter system. Preclinical studies have demonstrated the significance of serotonin receptors (5-HT1-3,6,7), its signal transduction pathways and classical down stream targets (including neurotrophins, neurokinins, other peptides and their receptors) in antidepressant drug action. Serotonergic control of depression embraces the recent molecular requirements such as influence on proliferation, neurogenesis, plasticity, synaptic (re)modeling and transmission in the central nervous system. The present progress report analyses the credibility of each protein as therapeutically relevant target of depression. In vivo interaction studies and knockout models which identified these targets are foreseen to unearth new ligands and help them transform to drug candidates. The importance of the antidepressant assay selection at the preclinical level using salient animal models/assay systems is discussed. Such test batteries would definitely provide antidepressants with faster onset, efficacy in resistant (and co-morbid) types and with least adverse effects. Apart from the selective ligands, only those molecules which bring an overall harmony, by virtue of their affinities to various receptor subtypes, could qualify as effective antidepressants. Synchronised modulation of various serotonergic sub-pathways is the basis for a unique and balanced antidepressant profile, as that of fluoxetine (most exploited antidepressant) and such a profile may be considered as a template for the upcoming antidepressants. In conclusion, 5-HT based multi-targeted antidepressant drug discovery supported by in vivo interaction studies and knockout models is advocated as a strategy to provide classic molecules for clinical trials.
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    Multi-Objective facility layout problem: A state-of-the-art review paper
    (ICFAI, 2008) Matai, Rajesh
    It has been over two decade since Rosenblatt (1979) published his work on multi-objective facility layout problem (MFLP). Since then, there have been modifications/ improvements to his work. Many other models to solve MFLP have also been proposed. Similarly, many heuristics and iterative procedures have been proposed to solve multi-objective facility layout problem. However, no comprehensive review work on multi-objective facility layout problem has been undertaken so far. In this paper we review the different works of research that have been carried out in the area of multi-objective facility layout problem particularly and discuss the future research directions.
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    Word of expertise to solve SCM issues
    (SCMS, Noida, 2009) Sharma, Satyendra Kumar; Bhat, Anil Kumar
    Su p p l y C h a i n M a n a g e m e n t i s a t t r a c t i n g t h e a t t e n t i o n o f a c a d e m i c i a n s a n d p r a c t i t i o n e r s . A l l t h r e e f u n c t i o n s i . e . m a n u f a c t u r i n g s u p p o r t , p r o c u r e m e n t a n d p h y s i c a l d i s t r i b u t i o n a r e t a k e n a s a s i n g l e a n d u n i f i e d f u n c t i o n . D i f f e r e n t c o m p a n i e s a r e i n v o l v e d t o p e r f o r m a l l t h e s e f u n c t i o n s a t t h e i r p r e m i s e s a r o u n d t h e w o r l d a t d i f f e r e n t l o c a t i o n s , b u t t h e u l t i m a t e o b j e c t i v e o f a l l s u p p l y c h a i n e n t i t i e s i s d e l i v e r i n g c u s t o m e r d e l i g h t . G l o b a l i z a t i o n , o u t s o u r c i n g e t c , a r e r e s p o n s i b l e f o r i n c r e a s e d d e p e n d e n c i e s a m o n g f i r m s . F i r m s a r e d e p e n d e n t o n e a c h o t h e r f o r t h e i r g o a l a c c o m p l i s h m e n t . Tw o t y p e s o f d e p e n d e n c i e s e x i s t b e t w e e n f i r ms: time dependencies and functional dependencies. This paper examines how the supply chain management solves the s t r a t e g i c i s s u e s m a i n l y r e l y i n g o n l i t e r a t u r e a n d o p i n i o n s o f e x p e r t s i n t h e f i e l d .
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    Consumer reactions to retail out-of-stock: replication into new contexts
    (Inder Science, 2008-04) Rani, Leela
    This study empirically examines the impact of situational, consumer, store and product characteristic variables on consumers' behavioural reactions in out-of-stock situations in retail. A survey method for data collection was used with a sample of 1,207 retail customers in India's unorganised retail sector across five product categories in Varanasi, India. Results showed that 11 out of 13 independent variables had a significant impact on at least one of the three behavioural responses considered. As the data was collected only for five product categories and for unorganised retail setting, findings are not generalisable beyond these limitations. Empirical research like this helps to develop an understanding about the consumer behaviour which differs widely across settings. It is one of the first studies in an unorganised retail in India. Study provides crucial insights to the retailers by identifying independent variables that must be considered while designing their operations and strategies to fight out-of-stock. Implications for the retailers and the future research are discussed.
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    Understanding consumer’s attitude towards retail store in stockout situations
    (Emerald, 2007) Rani, Leela
    This study aims to examine empirically how consumers’ attitude towards retail stores gets affected by situational, consumer, store and product characteristic variables when they face outof-stock situations.
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    Evaluating performance of national R&D organizations using integrated DEA‐AHP technique
    (Emerald, 2008-06) Tikoria, Jyoti
    The purpose of this paper is to evaluate and compare the performance of national R&D organizations in India in terms of their relative efficiencies using a multiple output measurement criteria incorporating the quality of the output measures.
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    Performance measurement of national R&D organisations using analytic hierarchy process: a case of India
    (Inder Science, 2009) Tikoria, Jyoti
    Evaluating and comparing the performance of different R&D organisations in a homogeneous or heterogeneous group in the fairest way is a very complex and yet challenging task. This paper provides a framework and a system to the national policy makers and the performance monitoring committee for designing a standard multiple performance measurement criteria for evaluating and comparing the performance of national R&D organisations. In this paper, analytic hierarchy process (AHP) technique has been applied to develop the framework of multiple performance measurement criteria, deriving their respective weights and system for comparing the performance of a group of Indian national R&D organisations involved in applied as well as basic research in chemical and botanical sciences. The framework and the system developed have been applied by taking an illustration to evaluate and compare the performance of six national R&D organisations in terms of their benefit-cost ratio.
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    Dynamic Optimal Advertising Expenditure Strategies for Two Successive Generations of High Technology Products
    (World Scientific, 2009) Chanda, Udayan
    Advertising plays a very important role in drawing consumer attention to new-products and in encouraging early adoptions. The problem of drawing optimal advertising plans for innovations have therefore has received a lot of attention from marketing managers and researchers. But there is need for further research on problems pertaining to new-products that are part of technological generations. This chapter deals with the determination of optimal advertising expenditure for two-generation consumer durables. The model considers intergenerational diffusion effect and also introduces a framework for modeling innovation diffusion for two competing generations.
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    A model for adoption of successive generations of a high technology product
    (Inder Science, 2007) Chanda, Udayan
    Modelling the new product sales growth and forecasting future sales has been an important area of research in Marketing Science. Models have been proposed to map the consumer buying behaviour against explanatory variables such as price, promotional effort, quality, time, etc. In comparison, high technology products have received less attention. These products usually have many generations, each succeeding generation being an improvement over the previous one. This paper discusses some well-known models in this area and also proposes a new one. The new model uses the relationship between the repeat purchasers and the new purchasers in the overall diffusion of a new technology over multiple generations, by separately identifying the two types of adopters. This model has been validated on sales-data and has also been compared to an established model.