BITS Faculty Publications

Permanent URI for this communityhttp://localhost:4000/handle/123456789/1867

Browse

Filter results by typing the first few letters
Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Click chemistry inspired synthesis of piperazine-triazole derivatives and evaluation of their antimicrobial activities
    (Springer, 2015) Jha, Prabhat N.; Kumar, Anil
    A series of novel piperazine-1,2,3-triazole derivatives, which entailed the bioisosteric replacement of the imidazole moiety and hybridization of two drug scaffolds was prepared by employing the regioselective copper (I)-catalysed azide-alkyne 1,3-dipolar cycloaddition reaction. The synthesized compounds were evaluated for antibacterial activities against Gram-negative (E. Coli and P. Putida), Gram-positive S. Aureus bacteria and fungicidal activities against F. oxysporum, F. gramillarium and F. monalliforme fungi. Compound 7ac′ exhibited moderate but promising antibacterial activity against Gram-negative bacteria and fungicidal activity against F. oxysporum and F. gramillarium.
  • No Thumbnail Available
    Item
    A Facile Synthesis and Cytotoxicity of a Novel Porphyrin-Cryptolepine Conjugate
    (CBI, 2012) Kumar, Anil; Kumar, Dalip
    A novel porphyrin–cryptolepine conjugate 7 with a 1,2,3-triazole linker was synthesized by the cycloaddition reaction of propargyl porphyrin 2 and azido cryptolepine 6 under click conditions. The conjugate 7 exhibited enhanced photocytotoxicity against A549 cells with IC50 values of 2.5 μM and 7.9 μM in the visible and UV light, respectively.
  • No Thumbnail Available
    Item
    Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities
    (Elsiever, 2011-03) Kumar, Anil
    A series of two classes of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates were synthesized using click chemistry approach. All compounds were evaluated for inhibition of Src kinase and human ovarian adenocarcinoma (SK-Ov-3), breast carcinoma (MDA-MB-361), and colon adenocarcinoma (HT-29). Hexyl triazolyl-substituted 3-phenylpyrazolopyrimidine exhibited inhibition of Src kinase with an IC50 value of 5.6 μM. 4-Methoxyphenyl triazolyl-substituted 3-phenylpyrazolopyrimidine inhibited the cell proliferation of HT-29 and SK-Ov-3 by 73% and 58%, respectively, at a concentration of 50 μM.