BITS Faculty Publications
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Item Recent Progress in Hot Melt Extrusion Technology in Pharmaceutical Dosage Form Design(Bentham Science, 2022-09) Jindal, Anil B.The Hot Melt Extrusion (HME) technique has shown tremendous potential in transforming highly hydrophobic crystalline drug substances into amorphous solids without using solvents. This review explores in detail the general considerations involved in the process of HME, its applications and advances.Item Nano-natural Products as Anticancer Agents(Springer, 2018-07) Paul, Atish Tulshiram; Jindal, Anil B.Cancer is one of the noxious diseases and is a major public health problem worldwide. The clinical management of cancer involves various approaches, but the most common one is chemotherapy. Natural products such as paclitaxel, camptothecin, podophyllotoxin, etc. have been used as major sources of anticancer drugs in many clinical trials. In spite of availability of these drugs for treatment of cancer, failure in chemotherapy is very common due to dose-limited toxicities and occurrence of drug resistance. In this regard, the nano-delivery systems directly target and deliver the selective drug to the cancerous sites and increase the permeability and intracellular accretion of anticancer drugs. Thus, the aim of this chapter is to focus on the application of nanotechnology to develop nano-natural products for effective treatment of cancer.Item Nanotechnology Based Delivery of Nutraceuticals(Springer, 2018-11) Paul, Atish Tulshiram; Jindal, Anil B.With the growing worldwide population, there is increase in prevalence of various diseases like cancer (0.338%), hyperlipidemia (39%), hypertension (44.5%), infectious disease (17 million/ annum), diabetes (18.4%), obesity (25.9%) and osteoporosis (200 million/ annum). Nutraceutical seek their application in prophylaxis and cure of these diseases for instance, coenzyme Q-10, polyphenols, isoflavone, flavones, carotenoid, isocyanidine for treatment of cancer and other life threatening diseases, elements like zinc as prophylactic treatment to maintain metabolism, calcium and magnesium to maintain bone health, Selenium as an anti-oxidant, vitamin D for osteoporosis, vitamin E & C as anti-oxidant for prevention of cancer and vitamin B-complex for proper functioning of nervous system. However, nutraceuticals have certain limitations including poor solubility, absorption and bioavailability, chemical instability and higher first pass metabolism which can be overcome by nano-delivery of nutraceutical