Copper-Catalyzed One-Pot Tandem Reaction for the Synthesis of Imidazo[1,2-c][1,2,3]triazolo[1,5-a]quinazolines
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Date
2007-10-06
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Publisher
Wiley
Abstract
A Cu-catalyzed tandem reaction of 2-(2-bromoaryl)imidazoles/2-(2-bromoaryl)benzmidazoles, alkynes, and sodium azide is developed for the synthesis of imidazo[1,2-c][1,2,3]triazolo[1,5-a]quinazolines in moderate to excellent yields. This one-pot protocol includes copper-catalyzed azide–alkyne cycloaddition (CuAAC), intramolecular cross-dehydrogenative coupling (CDC), and Ullmann-type C–N coupling.
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Keywords
Chemistry, Copper-Catalyzed, Synthesis of Imidazo