Antidepressant-like activity of (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone (4a), a novel 5-HT3 receptor antagonist: An investigation in behaviour-based rodent models of depression
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Date
2012-09
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Publisher
Wolters Kluwer
Abstract
The present study was designed to investigate the antidepressant potential of (4-phenylpiperazin-1-yl) (quinoxalin-3-yl) methanone (4a), a novel 5-HT3 receptor antagonist, with an optimal log P (2.84) and pA2 value (7.3) greater than ondansetron (6.9) using rodent behavioural models of depression.
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Keywords
Pharmacy, (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone, 4a, 5-HT3 receptor antagonist, Depression, Forced swim test (FST), Olfactory bulbectomy (OBX)