Neuroprotective effects of the epigenetic modulator decitabine in 6-OHDA-Induced cellular and mouse models of Parkinson's disease

Abstract

Oxidative stress is one of the factors in Parkinson’s disease (PD) etiology. Genes implicated in PD, such as DJ-1, PARKIN and PINK1, contribute to oxidative stress, affecting dopaminergic neurons. The Xlinked G6PD gene encodes glucose 6-phosphate dehydrogenase, an important regulator of oxidative stress. Conflicting reports have shown both reduced G6PD activity and elevated G6PD expression levels in PD patients, leading to inconsistent conclusions about its role in PD.