Neuroprotective effects of the epigenetic modulator decitabine in 6-OHDA-Induced cellular and mouse models of Parkinson's disease

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dc.contributor.authorTaliyan, Rajeev
dc.date.accessioned2025-11-11T09:18:26Z
dc.date.available2025-11-11T09:18:26Z
dc.date.issued2025-05
dc.description.abstractOxidative stress is one of the factors in Parkinson’s disease (PD) etiology. Genes implicated in PD, such as DJ-1, PARKIN and PINK1, contribute to oxidative stress, affecting dopaminergic neurons. The Xlinked G6PD gene encodes glucose 6-phosphate dehydrogenase, an important regulator of oxidative stress. Conflicting reports have shown both reduced G6PD activity and elevated G6PD expression levels in PD patients, leading to inconsistent conclusions about its role in PD.en_US
dc.identifier.urihttps://www.prd-journal.com/article/S1353-8020(25)00141-5/fulltext
dc.identifier.urihttps://dspace.bits-pilani.ac.in/handle/123456789/20019
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectPharmacyen_US
dc.subjectParkinson’s diseaseen_US
dc.subjectOxidative stressen_US
dc.subjectG6PD geneen_US
dc.subjectEnzyme activityen_US
dc.subjectDopaminergicen_US
dc.titleNeuroprotective effects of the epigenetic modulator decitabine in 6-OHDA-Induced cellular and mouse models of Parkinson's diseaseen_US
dc.typeArticleen_US

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