Influence of multiple re-infections in tuberculosis transmission dynamics: A Mathematical Approach

Abstract

This investigation accounts a TB transmission model with the possibility of both exogenous re-infections and recurrent TB. The qualitative characteristic of the model system has been analyzed covering stability of existing equilibrium points and bifurcation criteria. The basic reproduction number is obtained by using the next-generation matrix method. It has been observed that the system performs a backward bifurcation at Ro = 1 and hence Ro <; 1 can not guaranty the disease elimination. Several numerical simulations have been performed to support the analytical findings.