High fat diet feeding exacerbates the toxic effects of 6-hydroxydopamine in rats: Possible involvement of histone acetylation

Abstract

Clinical evidence has shown a correlation between Parkinson's disease (PD) and type 2 diabetes, as abnormal glucose tolerance has been reported in >50% of PD patients. Recently, insulin resistance was found to be present in 62% of PD patients with dementia, of whom 30% were glucose intolerant [1]. However, the underlying pathways are still elusive. Therefore, the present study was designed to explore the effect of insulin resistance on striatal dopaminergic neurons in an animal model of PD.