Facile β-Alkyl and β-Hydride Elimination in the Nickel-Catalyzed Annulation of o-Iodophenyl Ketones and Aldehydes with Bicyclic Alkenes
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Date
2006-05-26
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ACS
Abstract
o-Iodoaryl aldehydes react with bicyclic alkenes in the presence of NiBr2(dppe) and Zn powder in acetonitrile at 80 °C undergoing annulation to give polycyclic ketone derivatives. Surprisingly, o-iodoaryl alkyl ketones also react with bicyclic alkenes to form polycyclic ketones with structures the same as those from the corresponding o-iodoaryl aldehydes.
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Keywords
Chemistry, Hydrocarbons, Annulations, Reaction products